| Label | Attribute |
|---|---|
| Calatog Num1·ber | BP001 |
| Synonyms | Abeta 1-28 |
| Product Description | Beta amyloid is an extracellular filamentous protein deposit found in the brain. It is the major protein component of amyloid cores and neuritic plaques and is also found as a deposit in neurofibrillary tangles. Beta-amyloid peptide (Abeta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). Beta-amyloid peptide is generated from the beta-amyloid precursor protein (beta APP) in a two-step process. |
| CAS No. | 109770-29-8 |
| Purity | ≥ 95% by HPLC |
| Molecular Weight | 3262.5 |
| Formula | C145H209N41O46 |
| Storage | -20 °C |
| Sequence (One-Letter Code) | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Sequence (Three-Letter Code) | Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys |
| Solubility | Soluble in water. The contents of this vial have been accurately determined. Both the stopper and the vial have been siliconized. Do not attempt to weight out a smaller portion of the contents. |
| Citations | Gorbita CH. The structure of nanotubes formed by diphenylalanine, the core recognition motif of Alzheimer's beta-amyloid polypeptide. Chem. Commun(Camb). Jun 2006; 14(22 ): 2332-2334. |
| Song Y, et al. Comparison of MR images and histochemical localization of intra-arterially administered microglia surrounding beta-amyloid deposits in the rat brain. Histol. Hist opathol. Jul 2006; 21(7): 705-711. | |
| Park HY, et al. Modulation of neutrophil apoptosis by beta-amyloid proteins. Int. Immunopharmacol. Jul 2006; 6(7): 1061-1069. |
| Label | Attribute |
|---|---|
| Calatog Number | BP002 |
| Synonyms | Β-Amyloid; b-Amyloid; b-Amyloid; beta-Amyloid; beta-Amyloidβ-Amyloid |
| Product Description | Beta amyloid (42-1) is the reverse of beta amyloid (1-42), the latter is a member of beta amyloid-peptides, which are involved in the amyloid beta-peptide (A beta)-associated f ree radical oxidative stress model for neuronal death in Alzheimer's disease (AD) brain. |
| Purity | ≥ 95% by HPLC |
| Molecular Weight | 4514.4 |
| Formula | C203H311N55O60S1 |
| Storage | -20 °C |
| Sequence (One-Letter Code) | AIVVGGVMLGIIAGKNSGVDEAFFVLKQHHVEYGSDHRFEAD |
| Sequence (Three-Letter Code) | Ala-Ile-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp |
| Citations | Anderson OA., etc. A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome. PLoS One. 2013Jun;8(6):e67263. |
| Label | Attribute |
|---|---|
| Calatog Num1·ber | BP003 |
| Synonyms | Diabetes-Associated Peptide (DAP), amide, humanInsulinoma or islet amyloid polypeptide (IAPP) |
| Product Description | Amylin, a 37-amino acid polypeptide that is structurally related to calcitonin, is secreted from the B cells of the pancreas. Amylin has anoretic effects in rats. Amylin may be res ponsible for the etiology of insulin resistance of type II diabetes mellitus through its modulation of peripheral effects of insulin. Amylin blocks the activation of glycogen synth ase by insulin. |
| Purity | ≥ 95% by HPLC |
| Molecular Weight | 3903.28 |
| Formula | C165H261N51O55S2 |
| Disulfide Bridge | Disulfide Bridge: Cys2-Cys7 |
| Storage | -20 °C |
| Sequence (One-Letter Code) | KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY-NH2 |
| Sequence (Three-Letter Code) | Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 |
| Solubility | Can be dissolved in DMSO or DMF first and then dilute with water |
| Citations | Konarkowska B, et al. Thiol reducing compounds prevent human amylin-evoked cytotoxicity. FEBS J. Oct 2005; 272(19): 4949-4959. |
| Kajava AV, et al. The parallel superpleated beta-structure as a model for amyloid fibrils of human amylin. J. Mol. Biol. Apr 2005; 348(2): 247-252. | |
| Guerreiro LH., etc. Polymeric particles for the controlled release of human amylin. Colloids Surf B Biointerfaces. 2012 Jun;94:101-6. | |
| Kevin Hartman., etc. Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences. PeerJ. 2013 Feb;12(1):e5. |
| Label | Attribute |
|---|---|
| Calatog Num1·ber | BP004 |
| Product Description | Beta amyloid 1-42 is known as a biomarker of Alzheimer's disease. Amyloid is detectable in cerebrospinal fluid (CSF). It is a 42-amino acid fragment of amyloid precursor protei n. The peptide is well suited for use as a standard in the quantitation of Alzheimer's. |
| CAS No. | 107761-42-2 |
| Purity | ≥ 95% by HPLC |
| Molecular Weight | 4514.14 |
| Formula | C203H311N55O60S1 |
| Storage | -20 °C |
| Sequence (One-Letter Code) | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Sequence (Three-Letter Code) | Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-I le-Ala |
| Solubility | Soluble in water |
| Citations | Ambroggio EE, et al. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. Apr 2005; 88(4): 2706-2713. |
| Mathew A., etc. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One.2012 Mar;7(3):e32616. | |
| R Banerjee. etc. Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide. Spectrochim Acta A Mol Biomol Spectrosc.2013 Sep; | |
| Anila Mathew etc. Amyloid-Binding Aptamer Conjugated Curcumin-PLGA Nanoparticle for Potential Use in Alzheimer’s Disease. BioNanoScience. 2012 Jun; 2 (2); 83-93. |
| Label | Attribute |
|---|---|
| Calatog Num1·ber | BP005 |
| Synonyms | Abeta 1-42, ratβ-Amyloid Peptide; |
| Product Description | Abeta 1-42 induces a strong membrane destabilization in giant unilamellar vesicles composed of palmitoyloleoyl-phosphatidylcholine, sphingomyelin, and cholesterol, lowering the critical tension of vesicle rupture. Additionally, Abeta 1-42 triggers the induction of sequential leakage of low- and high-molecular-weight markers trapped inside the giant unilamellar vesicles, but preserving the vesicle shape. The Abeta 1-42 sequence confers particular molecular properties to the peptide that, in turn, influence supramolecularpro perties associated with membranes that may result in toxicity,including: 1) the ability of the peptide to strongly associate with the membrane; 2) a reduction of lateral membrane cohesive forces; and 3) a capacity to break the transbilayer gradient and puncture sealed vesicles. |
| Purity | ≥ 95% by HPLC |
| Molecular Weight | 4418.1 |
| Formula | C199H307N53O59S1 |
| Storage | -20 °C |
| Sequence (One-Letter Code) | DAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| Sequence (Three-Letter Code) | Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala |
| Citations | Folin M, et al. Apolipoprotein-E modulates the cytotoxic effect of beta-amyloid on rat brain endothelium in an isoform-dependent specific manner. Int J Mol Med. May 2006;17(5 ):821-826. |
| Chen L, et al. alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats. Neuropharmacology. Feb 2006;50(2 ):254-268. | |
| Bastianetto S, et al. Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity. Eur J Neurosci. Jan 2006;23(1):55-64. |
